Angio-Metabolic Study
Study endpoints
The Angiometabolic Study is an ongoing, prospective two-centre cohort from Greece and Germany that investigates how metabolic syndrome traits and aging interact to drive subclinical and clinically overt vascular disease.
Since inception the study has enrolled 2,150 participants (target ≥2,800) and already has follow-up data on 1,100 individuals (median 24 months).
At baseline and at every follow-up visit (yearly for the first two years, then every two years) investigators collect a rich exposome panel encompassing plasma, serum and whole blood samples; anthropometrics and ultrasound-based fat-layer measurements; detailed dietary, smoking and exercise questionnaires; and traditional cardiometabolic risk factors.
Outcomes are assessed in parallel at each visit. Vascular imaging quantifies atherosclerosis burden and progression in the carotid–femoral axis, carotid–femoral pulse-wave velocity, microvascular reactivity, and office/24-hour ambulatory blood-pressure profiles (including aortic BP, pulse-wave analysis and central PWV). Coronary artery calcification scores and coronary CT atherosclerosis grading are captured when available, while clinical follow-up focuses on major adverse cardiac events.
By integrating high-resolution vascular ultrasonography, advanced hemodynamic measurements and a comprehensive exposome (metabolic parameters, IL-6, Aβ40 and other circulating biomarkers), the Angiometabolic Study provides an unrivalled platform to identify metabolic and inflammatory signatures that predict residual cardiovascular risk and to inform novel preventive strategies in aging populations.
Subclinical Vascular Disease
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Carotid–femoral atherosclerosis burden and plaque progression by high-resolution ultrasonography
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Carotid–femoral pulse-wave velocity (macrovascular stiffness)
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Microvascular function (reactive hyperaemia/venous occlusion plethysmography)
Hemodynamic Profiles
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Office and 24-hour ambulatory blood pressure, including aortic (central) BP
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Pulse-wave analysis and central PWV parameters
Vascular Imaging
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High-resolution ultrasonography of peripheral arteries
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Total coronary artery atherosclerosis burden and lesion characterization by CT angiography
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Coronary artery calcium (CAC) score
Clinical Outcomes
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Incident and recurrent ASCVD events (myocardial infarction, coronary revascularization, stroke, peripheral arterial events)
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Hospitalisation for heart failure and other major adverse cardiac events (MACE)
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Cardiovascular and all-cause mortality